WebMD Medical News
Louise Chang, MD
Feb. 25, 2008 -- Scientists may be one step closer to creating a blood test for bipolar disorder and other mood disorders.
Mood disorders may have blood biomarkers -- chemicals in blood -- that can be detected, new research shows.
In a preliminary study, researchers identified 10 biomarkers in blood samples from adults with bipolar disorder.
Those biomarkers "may offer an unexpectedly informative window into brain functioning and disease state," write the researchers, who included A.B. Niculescu III, MD, PhD, assistant professor of psychiatry, medical neurobiology, and neuroscience at Indiana University's medical school.
First, 29 bipolar patients provided blood samples and rated their mood. Mood ratings were high for 13 patients, low for 13 other patients, and intermediate for the last three patients.
By analyzing those blood samples, the researchers came up with a list of genes that were more or less active in patients with high and low moods.
Next, the scientists winnowed down the gene list, based on lab tests in mice and brain tissue from people who had died with bipolar disorder, depression, and other mood disorders.
Based on all that work, the scientists identified 10 biomarkers -- five linked to high mood and five tied to low mood -- in bipolar patients.
Lastly, Niculescu's team measured those biomarkers in 19 other bipolar patients and 30 patients with psychotic disorders. The biomarkers weren't perfect at identifying patients with high and low mood, but they were right 60% to 70% of the time.
The study appears in the journal Molecular Psychiatry.
SOURCES:Le-Niculescu, H. Molecular Psychiatry, Feb. 26, 2008; advance online
edition.News release, Indiana University.News release, Molecular Psychiatry.
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